HOXB2

HOXB2
Identifiers
Aliases	HOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDs	OMIM: 142967; MGI: 96183; HomoloGene: 37584; GeneCards: HOXB2; OMA:HOXB2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 48,540,894 bp End 48,545,109 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 59.85 cM Start 96,241,351 bp End 96,244,838 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula right uterine tube corpus epididymis muscle layer of sigmoid colon caput epididymis left coronary artery gastric mucosa Descending thoracic aorta right coronary artery canal of the cervix Top expressed in embryo somite tail of embryo transitional epithelium of urinary bladder seminal vesicula proximal tubule adrenal gland right kidney enteric nervous system medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm cytosol nuclear speck Biological process multicellular organism development regulation of transcription, DNA-templated blood circulation transcription, DNA-templated morphogenesis of an epithelial sheet anterior/posterior pattern specification dorsal/ventral pattern formation rhombomere 3 development rhombomere 4 development facial nerve structural organization embryonic skeletal system morphogenesis skeletal system morphogenesis neural nucleus development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3212 103889 Ensembl ENSG00000173917 ENSMUSG00000075588 UniProt P14652 P0C1T1 RefSeq (mRNA) NM_002145 NM_134032 RefSeq (protein) NP_002136 NP_598793 Location (UCSC) Chr 17: 48.54 – 48.55 Mb Chr 11: 96.24 – 96.24 Mb PubMed search
Wikidata
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Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.

See also

• Homeobox

Further reading

• Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7318–22. Bibcode:1991PNAS...88.7318L. doi:10.1073/pnas.88.16.7318. PMC 52286. PMID 1871139.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". The EMBO Journal. 7 (7): 2131–8. doi:10.1002/j.1460-2075.1988.tb03052.x. PMC 454515. PMID 2901346.
• Vieille-Grosjean I, Huber P (Mar 1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". The Journal of Biological Chemistry. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.
• Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC 395231. PMID 7913891.
• Guazzi S, Pintonello ML, Viganò A, Boncinelli E (May 1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological Chemistry. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
• Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron. 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.
• Case SS, Huber P, Lloyd JA (Nov 1999). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA and Cell Biology. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
• Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". The American Journal of Pathology. 158 (3): 955–66. doi:10.1016/S0002-9440(10)64042-4. PMC 1850338. PMID 11238043.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
• Liu X, Zhang X (Feb 2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi. 5 (1): 12–5. PMID 11835749.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene. 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
• Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clinical Cancer Research. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264. S2CID 15485235.

External links

• HOXB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.